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Kresge Eye Institute

Y. Shira Kresch, O.D., M.S., F.A.A.O.

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Director of Optometry
Wayne State University School of Medicine
Kresge Eye Institute
Specialty: Comprehensive ophthalmology, complex glasses refraction, contact lens fittings: Pediatric and Adult, Astigmatism, Multifocal, Myopia control
Optometry school: SUNY College of Optometry
Residency: NY VA Harbor Healthcare System, Brooklyn, New York
Fellowship: Fellow of the American Academy of Optometry
Appointment locations: Southfield and Detroit
Board Certification: National Board of Examination of Optometry
Clinical Interests: Dry Eye Syndrome, Medical Glaucoma
Research Interests: Tele-ophthalmology, Glaucoma Imaging, Patient Education, Myopia Control
Special Activities: 
Founder and President, Academic Optometry Society
Program Co-Chair, Optometric Glaucoma Society

Maryam Tahvildari, M.D.

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Assistant Professor, Department of Ophthalmology Wayne State University School of Medicine Kresge Eye Institute Specialty: ​Cornea and External Diseases Medical School: Tehran University of Medical Sciences (TUMS) Research Fellowship: Farabi Eye Hospital/TUMS, Schepens Eye Research Institute/Harvard Medical School Residency: Kresge Eye Institute/Wayne State University School of Medicine Clinical Fellowship: Cornea and Refractive Surgery fellowship at Massachusetts Eye & Ear/Harvard Medical School Appointment Location: Detroit Clinical Interests: Medical and surgical management of cornea and ocular surface diseases, corneal transplantation, cataract surgery, refractive surgery Selected Publications: 
  1. Tahvildari M, Singh RB, Saeed H. Application of Artificial Intelligence in the Diagnosis and Management of Corneal Diseases. Seminars in Ophthalmology. 2021 Mar 9:1-8. PMID: 33689543.
  2. Bal S, Tahvildari M, Jurkunas U. Scleral Perforation Secondary to Cyclophotocoagulation. Ophthalmology. 2021 May;128(5):662. PMID: 33892901.
  3. Tahvildari M, Dana R. Low dose interleukin-2 therapy in transplantation, autoimmunity and inflammatory diseases. Journal of Immunology. December 2019. PMID: 31740549.
  4. Shao C, Chen Y, Nakao T, Amouzegar A, Yin J, Tahvildari M, Lužnik Z, Chauhan SK, Dana R.  Local delivery of regulatory T cells promoted corneal allograft survival. Transplantation. January 2019. PMID: 30247445.
  5. Tahvildari M, Inomata T, Amouzegar A, Dana R. Regulatory T cell modulation of cytokine and cellular networks in corneal allograft rejection. Current Ophthalmology Reports. October 2018. PMID: 31807370.
  6. Tahvildari M, Amouzegar A, Foulsham W, Dana R. Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation. Cellular and Molecular Life Sciences. January 2018. PMID: 29307015.
  7. Tahvildari M, Emami-Naeini P, Omoto M, Mashaghi A, Chauhan SK, Dana R. Treatment of donor corneal tissue with immunomodulatory cytokines: a novel strategy to promote graft survival in high-risk corneal transplantation. Scientific Reports. April 2017. PMID: 28428556.
  8. Di Zazzo A, Tahvildari M, Subbarayal B, Yin J, Dohlman TH, Inomata T, Mashaghi A, Chauhan SK, Dana R. Proangiogenic function of T cells in corneal transplantation. Transplantation.August 2016. PMID: 27490416.
  9. Di Zazzo A, Tahvildari M, Florakis GJ, Dana R. Ocular manifestations of inherited phospholipase-Cγ2-associated antibody deficiency and immune dysregulation. Cornea. July 2016. PMID: 27442322.
  10. Hua J, Stevenson W, Dohlman TH, Inomata T, Tahvildari M, Calcagno N, Pirmadjid N, Sadrai Z, Chauhan SK, Dana R. Graft site microenvironment determines dendritic cell trafficking through the CCR7-CCL19/21 axis. Investigative Ophthalmology and Visual Science. March 2016. PMID: 27031839.
  11. Tahvildari M, Omoto M, Chen Y, Emami-Naeini P, Inomata T, Dohlman TH, Kaye AE, Chauhan SK, Dana R. In vivo expansion of regulatory T cells by low-dose interleukin-2 treatment increases allograft survival in corneal transplantation. Transplantation. March 2016 Mar. PMID: 26881788.
  12. Mohammadi SF, Tahvildari M, Abdolahi-Nia T. Pupil size and LASIK. Ophthalmology. April 2012. PMID: 22472258.
  13. Hashemian MN, Z-Mehrjardi H, Moghimi S, Tahvildari M, Amiri HM. Prevention of corneal neovascularization: comparison of different doses of subconjunctival bevacizumab with its topical form in experimental rats. Ophthalmic Research. January 2011. PMID: 21212709.
 

Aleksey Mishulin, M.D.

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Assistant Professor, Department of Ophthalmology Wayne State University School of Medicine Kresge Eye Institute Specialty: LASIK, Refractive Surgery, and Cataract Surgery Medical School: Wayne State University School of Medicine Residency: Kresge Eye Institute Appointment Locations: Detroit and Troy Board Certification: American Board of Ophthalmology Clinical Interests: LASIK, PRK, Refractive and Complex Cataract Surgery Hobbies: Cooking, Guitar, Amaro Publications: Mishulin A, Arsenault S, Glybina I, Tomsak RL. Reversible retinoschisis following high voltage electrical injury evaluated with optical coherence tomography and electrophysiology. Am J Ophthalmol Case Rep. 2020;19:100760. Keen JA, Kennedy BJ, Mishulin A, et al. Adult Versus Pediatric Relapse and Recurrence in Orbital Inflammatory Syndrome. Ophthalmic Plast Reconstr Surg. 2020 Winker KP, Beaulieu R, Bevill L, Mishulin A, Black EH. Effects of Aspirin on Postoperative Bruising and Bleeding Complications in Upper Eyelid Surgery. Ophthalmic Plast Reconstr Surg. 2020 Mishulin, Aleksey MD; Gandhi, Sachin BA; Apple, Daniel MD; Lin, Xihui MD; Hu, Jonathan MD; Abrams, Gary W. MD: Inducible Transient Central Retinal Artery Vasospasm: A Case Report. Retinal Cases and Brief Reports; September 2017

Faisal Ridha Al-Timimi, M.D.

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Clinician
Wayne State University School of Medicine
Kresge Eye Institute

Specialty: Glaucoma and Cataract Surgery

Medical School: Northeast Ohio Medical University (NEOMED)

Residency: Howard University Hospital

Fellowship: Kresge Eye Institute, Detroit, Michigan

Appointment Locations: Detroit and Southfield

Board Certification: American Board of Ophthalmology

Clinical Interests: Glaucoma, cataracts, and comprehensive eye care. Resident education and clinical teaching.

Hobbies:Spending time with my family and children. Hoping against the odds for Cleveland sports teams to bring home a championship.

Publications:
Ridha F, Chin Loy K, Lopez-Beauchamp C, Khan B. Purtscher’s Retinopathy after airbag injury, six month progression and sequelae. Medical & Surgical Ophthalmology Research. 2017 November; 1 (1).
Kaleem M, Ridha F, Shwani Z, Swenor B, Goshe J, Singh A. Intraocular Pressure Trends after Descemet’s Stripping Automated Endothelial Keratoplasty. Cornea. 2017 April; Epub ahead of print.
Ridha F, Sarac S, Erzurum SA. Effect of strabismus surgery on the reading ability of school-age children. Clinical Pediatrics (Phila). 2014 Sep;53(10):937-42.
Ridha F, Erzurum SA. Cerebral venous thrombosis masquerading as pseudotumor cerebri in a paediatric patient. Journal of Paediatric Child Health. 2014 May; 50(5):419
Alshekhlee, A, Guerch MA, Ridha F, Chelimsky TC. Postural Tachycardia Syndrome with Asystole on Head-up Tilt Test. Clinical Autonomic Research 2008 Feb; 18(1):36-9.

Pradeepa Yoganathan, M.D.

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Specialty: Retina, Vitreoretinal Surgery

Medical School: Albany Medical College, Albany, NY

Residency: North Shore – Long Island Jewish Health System, Great Neck, NY

Fellowship: St. Michael’s Hospital, University of Toronto, Toronto, ON

Appointment Locations: Detroit

Board Certification: American Board of Ophthalmology & Ophthalmology, Fellow of the Royal College of Surgeons of Canada

Honors:
2011 – Teacher of the Year, Ophthalmology Residency Program, University at Buffalo
2010 – June Callwood Oustanding Achievement Award, Voluntarism in Ontario for St Michael’s cataract mission
2003 – Family Physician’s Regional Representation Award, Albany Medical College
2002 – Alumni Association Scholarship, Albany Medical College
2001 – Commitment to Montreal Community Scholarship, Luxme International
1998 – Montreal Children’s Hospital Research Institute Scholarship for research in Endocrine Genetics, McGill University
1998 – Rona and Irving Levitt Scholarship for research proposal in Oncology, McGill University
1998 – Caritas Internationalis – Outstanding Volunteer Award for mission to Croatia and dedication to Croatian Community in Montreal

Publications:
1. Lin, H, Lema G, Yoganathan, P. Prognostic indicators of visual acuity after open globe injury and retinal detachment repair. Retina 2016;36(4):750-757.
2. Lam WC, Albiani DA, Yoganathan P et al. for the CHROME Study Group. Real-world assessment of intravitreal dexamethasone implant (0.7 mg) in patients with macular edema: the CHROME study. Clinical Ophthalmology, 2015; 9:1255-68.
3.Ding J, Sieminski S, Yoganathan, P. Resolution of ocular siderosis glaucoma following removal of 30 year old intraocular foreign body. Can J Ophthalmol 2015;50(5):82-85.
4. Bregu M, Tesha PE, Wong DT, Giavedoni LR, Altomare F, Yoganathan P, Chow DR, Romano MR. Nausea and fluorescein injection speed. Ophthalmology 2012; 119(6):1281-1281.
5. Tesha PE, Giavedoni LR, Berger AR, Altomare F, Chow DR, Navajas EV, Yoganathan P, Wong DT, Principe A. Subconjunctival lidocaine before laser treatment: a randomized trial. Ophthalmology 2010;117(9):1810-4.
6. Yoganathan P, Berger AR. Topical Ketorolac in Vitreoretinal Surgery. Evidence Based Ophthalmology 2009;10(2):105-106.
7. Becker HM, Yoganathan P, Berger AR. Endophthalmitis post complicated cataract surgery associated with Klebsiella pneumoniae. Ann Ophthalmol 2009;41(34):189- 190.
8. Herschorn AB, Yoganathan P, Margolin EA, Berger AR. Inadvertent subretinal triamcinolone injection in a case of recurrent scleritis. Can J Ophthalmol 2009;44(4):33-34.
9. Yoganathan P, Conti S, Kavalec C. The use of intraoperative fluoroscopy as an aid for the removal of radiopaque intraorbital foreign bodies. Ophthalmic Surg Lasers Imaging 2008;39(5)436:4.
10. Ronan SM, Yoganathan P, Chien FY et al. Retinal pigment epithelium tears after intravitreal injection of bevacizumab (avastin) for neovascular age-related macular degeneration. Retina 2007;27(5):535-540.
11. Yoganathan P, Deramo VA, Lai JC, Fastenberg DM. Visual improvement following intravitreal bevacizumab (Avastin) in exudative age-related macular degeneration. Retina 2006;26(9):994-998.
12. Bakri SJ, Nickel J, Yoganathan P, Beer PM. Photodynamic therapy for choroidal neovascularization associated with submacular hemorrhage in age-related macular degeneration. Ophthalmic Surg Lasers Imaging 2006;37:278-283.
13. 2004 Yoganathan P, Meyer DR, Farber MG. Bilateral lacrimal gland involvement with Kimura disease in an African American male. Arch Ophthalmol 2004;122:917-919.

Xihui Lin, M.D.

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Assistant Professor, Department of Ophthalmology
Wayne State University School of Medicine
Kresge Eye Institute

Specialty: Uveitis, Vitreoretinal Surgery

Medical School: University of Texas Southwestern Medical Center

Residency: University of Texas Southwestern Medical Center

Fellowship: Retina, Kresge Eye Institute, Wayne State University

Appointment Locations: Detroit

Board Certification: American Board of Ophthalmology

Clinical Interests: Retinal Detachment, Diabetic Retinopathy, Macular Degeneration, Retinal Vascular Diseases, Inflammatory Retinal Diseases, Inherited Retinal Diseases, Retinopathy of Prematurity

Honors: Alpha Omega Alpha Medical Honor Society

Hobbies: Table Tennis, Clarinet, Fishing, Cooking

Recent Publications:
1. Lin X , Patel SB, Zhang A, Brill D, Le K, He YG. Fluorescein Angiography of Persistent Incomplete Vascularization of the Retina after Bevacizumab Therapy in Retinopathy of Prematurity. Journal of VitreoRetinal Diseases. 2019 April. 2. Padidam S, Burke M, Apple D, Hu J, Lin X . Possible Ledipasvir-sofosbuvir Associated Uveitis. JAMA Ophthalmology. 2019 Mar 28. PMID 30920588. 3. Malbin B, Padidam S, Burke M, Akhter M, Eby A, Mishulin A, Lin X . Intravenous Prostaglandin E1 Infusion for Acute Central Retinal Artery Occlusion. Ophthalmic Surgery Lasers Imaging Retina. 2019 (accepted for publication). 4. Malbin B, Patel HP, He Y, Le K, Lin X . Comparative Eye Effect of Unilateral Intravitreal Bevacizumab, Ranibizumab, and Aflibercept for Diabetic Macular Edema. Journal of VitreoRetinal Diseases. Feb 1, 2019. 5. Padidam S, Le K, Lin X. Refractive Trend of Stage 3 Retinopathy of Prematurity. J Pediatric Ophthalmol Strabismus. 2018 Nov 19;55(6):403-406. PMID: 30452767 6. Patel SB, Reddy N, Lin X, Whitson JT. Optical Coherence Tomography Retinal Nerve Fiber Layer Analysis in Eyes with Long Axial Lengths. Clinical Ophthalmology. 2018 May 3; 12:827-832. PMID 29765196 7. Mishulin A, Ghandi S, Apple D, Lin X, , Hu J, Abrams GW. Inducible Transient Central Retinal Artery Vasospasm: A Case Report. Retina Cases Brief Reports. 2017 Sep 27. PMID 28957956 8. Lin X., Apple D., Hu J., Tewari A. Advancements of vitreoretinal surgical machines. Current opinion in ophthalmology 28, no. 3 (2017): 242-245. PMID 28257298

Christopher Chapman, M.D.

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Assistant Professor, Department of Ophthalmology Wayne State University School of Medicine Kresge Eye Institute Specialty: Vitreoretinal Surgery Medical School: University of Washington School of Medicine Residency: Ophthalmology, Kresge Eye Institute/ Wayne State University Fellowship: Retina, University of California, Davis Appointment Locations: Detroit, Taylor, and Troy Board Certification: American Board of Ophthalmology Clinical Interests: Age-related Macular degeneration, Diabetic Retinopathy, Retinal detachment, Retinal Vascular Disease, Macular Pucker and Macular Hole

Gabriel Sosne, M.D.

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Associate Professor,
Department of Ophthalmology and Anatomy/Cell Biology
Wayne State University School of Medicine
Kresge Eye Institute

Website: www.drgabrielsosne.wordpress.com

Specialty: Cataract, Dry Eye Disease, Comprehensive Ophthalmology

Medical School: Albert Einstein College of Medicine, Yeshiva University

Residency: Ophthalmology, Henry Ford Hospital, Detroit, Michigan

Fellowship: National Institutes of Health, Bethesda, MD

Appointment Locations: Bingham Farms and Detroit

Board Certification: American Board of Ophthalmology

Clinical Interests: Cataract surgery, dry eye diease, diabetic eye exams, macular degeneration, inflammatory eye diseases, glaucoma, external eye diseases

Research Interests: Developing thymosin beta 4 as a novel therapy for corneal wound healing, inflammation, and dry eye disease

Special Activities: Member, American Academy of Ophthalmology; Member, Association for Research in Vision and Ophthalmology

Honors:

2011 AFER/Pfizer Ophthalmics Carl Camras Translational Research Award, ARVO, May 1, 2011, Fort Lauderdale, FL.

2012 Voted to Top Doctors Metro Detroit

2012 Top Ophthalmologist, International Association of Ophthalmologists

2013 Voted to Best Doctors of America

2014 Voted to Best Doctors of America

YouTube: 2017 Top Doctor

Publications:

Sosne G, Ousler GW. Thymosin β4 Ophthalmic Solution for Dry Eye: A Randomized, Placebo-Controlled Phase 2 Clinical Trial Conducted Using the Controlled Adverse Environment (CAE™) Model. Expert Opinion. In revision.

Sosne G, Kim C, Kleinman HK. Thymosin β4 Significantly Reduces the Signs of Dry Eye in a Murine Controlled Adverse Environment Model of Experimental Dry Eye. Expert Opinion. In press.

Sosne G, Dunn SP, Kim C. Thymosin beta 4 Significantly Improve Signs and Symptoms of Severe Dry Eye in a Phase 2 Clinical Trial. CORNEA In press.

Sosne G, Qiu P, Ousler GW 3rd, Dunn SP, Crockford D. Thymosin β4: a potential novel dry eye therapy. Ann N Y Acad Sci. 2012 Oct;1270:45-50. doi: 10.1111/j.1749-6632.2012.06682.x.

Goldstein, AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: A Multi-Functional Regenerative Peptide Basic Properties and Clinical Applications. Expert Opin Biol Ther. 2012 Jan;12(1):37-51. Epub 2011 Nov 10.

Qiu P, Wheater MK, Qiu Y, Sosne G. Thymosin beta 4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J. 2011 Feb 22, [Epub ahead of print]


Dunn SP, Heidemann DG, Chow CYC, Crockford D, Turjman N, Angel J, Allan CB, and Sosne G. “Treatment of Chronic Non-Healing Neurotrophic Corneal Epithelial Defects with Thymosin 4”

Ann N Y Acad Sci. 2010 Apr;1194:199-206. 

Dunn, SP, Heidemann DG, Chow CY, Crockford D, Turjman N,Angel, J, Allan CB, Sosne G. Arch Ophthalmol. Treatment of Chronic Nonhealing

Neurotrophic Corneal Epithelial Defects With Thymosin Beta 4. 2010 May; 128(5):636-8. 

Sosne G, Qiu P, Goldstein AL, Wheater MK. Biological activities of thymosin beta 4 defined by active sites in short peptide sequences. FASEB J. 2010 Jul;24(7):2144-51. Epub 2010 Feb 23. 

Sosne G, Qiu P, Christopherson PL, Wheater MK. Thymosin beta 4 suppression of corneal

NFkappaB: A potential anti-inflammatory pathway. Exp Eye Res. 2007 Apr;84(4):663-9. Gabriel Sosne, M.D.

Mark S. Juzych, M.D., M.H.S.A.

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The David Barsky, M.D. Endowed Chair
Professor and Chairman, Department of Ophthalmology Wayne State University School of Medicine
Director, Kresge Eye Institute

Specialty: Glaucoma

Medical School: Wayne State University School of Medicine

Residency: Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan

Fellowship: Glaucoma, Wilmer Eye Institute, Johns Hopkins University

Appointment Locations: Detroit, Southfield, Taylor and Troy

Board Certification: American Board of Ophthalmology

Clinical Interests: Glaucoma and cataracts

Research Interests: Surgical and pharmaceutical clinical trials, socioeconomics of ophthalmology, educational research

Special Activities: Associate Dean, GME, Wayne State University; Vice President, Academic Affairs, Detroit Medical Center; Member, Ophthalmology Residency Review Committee, ACGME

Honors: ACGME Parker J. Palmer “Courage to Teach” award, Best Doctors in America